Fred Hutchinson Cancer Research Center · company speakers →
Dr. Aude Chapuis will discuss her lab’s work on target identification, generation of high-affinity TCRs, cell process methodologies to translate these constructs into effective products for patients, clinical trial development and execution, and sophisticated high dimensional immune-monitoring to maximize the information that can be derived from each treated patient. Based on challenges encountered and lessons learned from previous adoptive T cell therapy trials, her lab is focusing on strategies that include eliciting increased tumor expression of the targeted HLA/peptides for better T cell recognition, maximizing T cell activation/proliferation/survival by engaging TCR-tethered co-stimulatory signals in CD4 and CD8 T cells. Dr. Chapuis will discuss the most recent strategies geared towards favoring localization and countering dysfunction of adoptively transferred TCR transgenic cells in vivo.
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