Hospital A Beneficênica Portuguesa de São Paulo · company speakers →
Dr. Phillip Scheinberg will review the mechanism of action of antithymocyte globulin (ATG), including the different formulations. Despite the mechanism of action of these polyclonal sera not being fully understood, they have been quite successfully applied in marrow failure syndromes and the conditioning regimens in transplantation, both bone marrow and solid organs. There are two main commercially available formulations, horse and rabbit ATG, which differ in their potency and effects on the immune system. Their introduction as therapy started decades ago, and they remain one of the few non-chemotherapeutic lymphocytotoxic agents. Their applications in different disease scenarios will be summarized.
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